WebDelta FosB is a truncated splice variant of FosB. [4] Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. WebWe show here that chronic, but not acute, administration of each of four drugs of abuse, cocaine, morphine, ethanol, and Delta (9)-THC, robustly induces DeltaFosB in nucleus accumbens, although different patterns in the core vs. shell subregions of this nucleus were apparent for the different drugs.
Frontiers Overexpression of DeltaFosB in nucleus accumbens …
WebSep 16, 1999 · More delta-FosB means that the balance of genetic switching in the nucleus accumbens is altered - for example, there may be more glutamate receptors than normal. WebMany of these molecular changes identified are now directly linked to the physiological and behavioral changes observed following chronic drug exposure. In addition, ΔFosB … the picnic art
Inside cocaine addiction Nature
WebAug 29, 2024 · Delta-FosB may be among the mechanisms by which the abuse of drugs can produce changes in the brain and contribute to the addiction phenotype. Delta-FosB, a member of the Fos family of transcription factors, accumulates within a subset of neurons of the nucleus accumbens and dorsal striatum after multiple administrations of illicit drugs. WebJun 12, 2014 · Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environmental enrichment has not been well studied. WebAbstract The transcription factor ΔFosB is upregulated in numerous brain regions following repeated drug exposure. This induction is likely to, at least in part, be responsible for the … the picnic austin