2024 Fhl2 transcription factor

Fhl2 transcription factor

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August undefined, 2024

WebNov 1, 2015 · The FHL2 regulation in the transcriptional circuitry of human cancers. The Four-and-a-half LIM (FHL)-only protein is a subfamily of protein members under the LIM … WebMesenchyme forkhead 1 (Mfh-1) is a transcription factor expressed in sclerotomal and craniofacial mesenchyme and in differentiating cartilage of mouse embryos.Mfh-1 – …

The four and a half LIM domains 2 (FHL2) regulates ovarian …

WebMar 21, 2024 · FHL2 (Four And A Half LIM Domains 2) is a Protein Coding gene. Diseases associated with FHL2 include Familial Isolated Dilated Cardiomyopathy and Rhabdomyosarcoma . Among its related pathways … • Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950. • Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi • Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950. • Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.389… indirect accounting

The FHL2 regulation in the transcriptional circuitry of human cance…

http://www.cancerindex.org/geneweb/FHL2.htm WebOct 20, 2024 · FHL2, a member of the four and a half LIM domain family, has been shown to serve either as an oncoprotein or as a tumor suppressor in various cancers. Our previous study showed that FHL2 plays a critical role in the initiation and progression of ovarian granulosa cell tumor via regulating AKT1 transcription. loctite muffler putty

FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt ...

WebBased on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left ventricular hypertrophy, diastolic dysfunction and increased … WebWe demonstrate that FHL2 interacts with beta-catenin, a key player involved in bone formation induced by Wnt signaling. FHL2-beta-catenin interaction potentiates beta-catenin nuclear translocation and TCF/LEF transcription, resulting in increased Runx2 and alkaline phosphatase expression, which was inhibited by the Wnt inhibitor DKK1. loctite na šroubyWebApr 5, 2002 · Nuclear localization of both FHL2 and IGFBP-5 was evident from Western immunoblot analysis and immunofluorescence. The role of FHL2 as an intracellular mediator of the effects of IGFBP-5 and other osteoregulatory agents in osteoblasts will need to be verified in future studies. ... Transcription Factors* Transfection Tumor Cells, Cultured … loctite n 1 instant power

"WebJan 18, 2013 · FHL2 cooperates with Arkadia in activation of Smad3/Smad4-dependent transcription. A, 293T cells were transfected with the TGF-β-responsive luciferase reporter (CAGA) 12-Luc (0.1 μg) together with Arkadia or C937A and increasing doses of FHL2 (0.1 μg and 0.3 μg). TK-Renilla was used as internal control. " - Fhl2 transcription factor

Fhl2 transcription factor

The four and a half LIM domains 2 (FHL2) regulates …

WebOct 1, 2024 · FHL2 interacts with Tissue Factor resulting in a reduction of its coagulation activity, and there is thus enhanced blood clot formation in FHL2-deficient mice. Furthermore, FHL2 SNP rs4851770 was shown to associate with the risk of developing venous thrombosis in humans [ 59 ]. WebJul 8, 2024 · Several forensic studies consistently found FHL2 to be one of the DNA methylation markers that correlate most significantly with ageing [ 6, 7, 8, 9 ]. FHL2 is …

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WebMechanistically, FHL2 overexpression enhanced nuclear accumulation of β-catenin and activated Wnt/β-catenin-dependent transcription leading to sustained upregulation of the early cardiogenic gene Igfbp5. WebJul 15, 2011 · The bioinformatic analysis identified putative binding sites of five transcription factors. We found that the Pax-5 and ZF5 expression was significantly correlated with FHL2 expression in HCC samples. These data suggest a possible role for these transcription factors in the regulation of FHL2 expression. 2. Materials and …

WebGain- and loss-of-function experiments revealed that FHL2 represses TF expression in endothelial and smooth muscle cells through inhibition of the transcription factors nuclear factor κB and activating protein-1. Furthermore, we observed that FHL2 interacts with the cytoplasmic tail of TF. WebNov 1, 2015 · FHL2 expression levels vary greatly depending on the cancer type that protein expresses. For example, FHL2 transcript levels are strongly enhanced in …

http://www.cancerindex.org/geneweb/FHL2.htm WebOct 1, 2024 · Four and a half LIM domains 2 (FHL2) is a key regulator of intracellular signal transduction pathways and the FHL2gene is consistently found as one of the top hyper-methylated genes upon aging. Remarkably, FHL2expression increases with methylation.

WebK.J. Baines, S.J. Renaud, in Progress in Molecular Biology and Translational Science, 2024 2.2.1.2 ASCL2. Achaete-scute family bHLH transcription factor 2 (ASCL2) is a bHLH …

WebJul 18, 2024 · Differentially expressed genes included several known regulators of bone metabolism, such as Gpnmb , Fhl2 , Mgp , Enpp1 and Phex . Figure 1. Co-culture of UMR-106 osteoblastic cells with prostate cancer cells (PC3) promotes changes in gene expression. ... These transcription factors have been shown to play a major role in … indirect action examplesWebFHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation, and FHL2 deficiency leads to decreased activity of ADAM-17 in mouse macrophages. loctite nabe welleWebSep 21, 2004 · ACT is a LIM-only protein that interacts with transcription factor CREM (123812) in postmeiotic male germ cells and enhances CREM-dependent transcription (Kotaja et al., 2004). ... ACT shares 58.5% identity with FHL2 (602633) and 85% identity with mouse Act. Northern blot analysis revealed moderate to high levels of expression in … indirect accounting methodWebCholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and cell context-specific manner. In this study, we aimed to gain insight into the function of FHL2 in cholestatic liver injury. FHL2 … loctite mr gs1WebSep 7, 2005 · Fhl2 increases the transcriptional activity of runt-related transcription factor 2 (Runx2), a key regulator of osteoblast function, and both proteins interact in vitro and in vivo. In summary, we present Fhl2-deficient mice as a unique model for osteopenia due to decreased osteoblast activity. indirect acting agonistWebRecently, we described FHL2 as a novel regulator of influenza A virus propagation. We have shown that in vitro FHL2 restricts viral replication by accelerating the interferon regulatory factor 3-dependent transcription of the Ifnb1 gene. In this work, we unraveled an ambiguous role of FHL2 during influenza A virus infection in vivo. indirect action message definitionWebApr 28, 2024 · FHL2 has been described as a coactivator for several transcription factors like the androgen receptor, AP-1 or β-catenin 21,34,35. In these studies, reporter gene experiments demonstrated that ... indirect action