Web1 jan. 2009 · The ketyl–olefin coupling was first described by Molander and coworkers, and variations of this reaction have been explored in many laboratories. As with the radical–alkene/alkyne reaction, the carbonyl–alkene/alkyne reaction may be performed with both activated[ 30 ] and unactivated alkenes and alkynes. WebThis enormous dynamic range suggests that we will be able to dramatically expand the scope of known radical generation technologies (and formal HAT catalysis). We have recently demonstrated the viability of these ideas in the development of a new catalytic protocol for ketyl olefin coupling (Figure 3).

Olefin cross-metathesis–based approaches to furans ... - Nature

WebAminosilane has been used as a coupling agent for cyclopentadienyl (Cp) ligands on silica surfaces. First the silica surface was functionalized with ... WebI have over 9 years of experience as a research scientist designing experiments, analyzing data, and drawing conclusions from the results. The last 2 years I have shared my passion for chemistry ... intex sf20110

Photoredox-Catalyzed Ketyl–Olefin Coupling for the Synthesis of ...

Web13 jun. 2024 · Several catalytic approaches have been developed to generate ketyl radicals and successfully applied in reductive cyclizations and two-component cross-coupling … WebKetyl-Olefin, Ketyl, electrochemical Grignard, electrochemical coupling, reductive coupling. ABSTRACT: A user-friendly approach to sidestep the venerable Grignard … WebThe ketyl radical center adds to the olefin, forming the 5-membered ring with complete stereoselectivity. The B-ring of 3 was also cyclized using the hydroxyl-directed pinacol coupling promoted by SmI2. After a series of steps, the hydroxy keto-aldehyde 1 was produced from the diol 52. intex sf20220r