Radiosensitivity is the relative susceptibility of cells, tissues, organs or organisms to the harmful effect of ionizing radiation. Cells are least sensitive when in the S phase, then the G1 phase, then the G2 phase, and most sensitive in the M phase of the cell cycle. This is described by the 'law of … Ver más The damage to the cell can be lethal (the cell dies) or sublethal (the cell can repair itself). Cell damage can ultimately lead to health effects which can be classified as either Tissue Reactions or Stochastic Effects according to the Ver más • Background radiation • Cell death • Lethal dose, LD50 • LNT model, Linear no-threshold response model for ionizing radiation Ver más Web21 de nov. de 2024 · OTUD4 enhances radiosensitivity in NPC cells by promoting GSDME-dependent pyroptosis. In order to further study the impact of OTUD4 on pyroptosis and radiosensitivity in NPC cells, HONE1 and 5-8F cells with or without OTUD4 overexpression were transfected with GSDME-shRNA, and we then examined their …
Investigation of Radiosensitivity Gene Signatures in Cancer Cell …
Web2 de jul. de 2024 · The individual response to ionizing radiation (IR) raises a number of medical, scientific, and societal issues. While the term "radiosensitivity" was used by the … mercy ave maria
Preclinical models in radiation oncology - Radiation Oncology
Web8 de mar. de 2016 · Numerous studies have investigated the range of human cellular radiosensitivity using several different endpoints; for example, cell survival, chromosome aberration induction, induction of apoptosis, and cell cycle checkpoint induction. In some cases, cellular radiosensitivity appears to be associated with increased cancer risk . Web13 de oct. de 2024 · In conclusion, variation in tumor radiosensitivity between different cell cycle phases is one of the rationales behind fractionation in radiation therapy. Such … WebRadiosensitivity is the response of the tumor to irradiation that can be measured by the extent of regression, rapidity of response, and response durability. Radiosensitivity … mercy awaits