WebMar 22, 2024 · ZURICH (Reuters) - Roche is calling it quits on a late-stage trial of its Huntington’s disease hopeful tominersen, the Swiss drugmaker said on Monday, a blow for sufferers of the rare,... WebJul 27, 2024 · Trial Summary. This study will test the safety, tolerability, pharmacokinetics and pharmacodynamics of RO7234292 administered intrathecally to adult patients with …
Decision to Stop Dosing in Tominersen Trial
WebBrian D. Roche. Brian is a senior counsel in the firm's Litigation Department and a member of the Intellectual Property Group. He has been recognized by ALM as a Top Rated Lawyer in … WebJan 23, 2024 · In an initial Phase I/II trial done by Ionis Pharmaceuticals and Roche, tominersen was shown to significantly reduce the levels of mutant HTT protein, the protein affected by the mutation responsible for HD, in the cerebral spinal fluid (CSF), the liquid surrounding the brain and spinal cord, of early stage patients 3. collocation firth
BN40697 - A study to look at tominersen safety over 15 …
WebMar 23, 2024 · Roches put an end to the Tominersen trial. (Robin Utrecht/SOPA Images/LightRocket via Getty Im) Ionis Pharmaceuticals, based in Carlsbad, California, announced that its collaboration partner, Roche, was discontinuing dosing in the Phase III GENERATION HD1 trial of tominersen in manifest Huntington’s disease (HD).No new … Webat the Huntington’s Disease Society of America. Hopes had been especially high for Roche’s tominersen, licensed from Ionis Pharmaceuticals in 2024. The drug was the first and only huntingtin (HTT)- lowering candidate to make it into pivotal trials. Roche has now halted the trial. “We had been hear - ing about it for over a decade. It was ... WebMay 7, 2024 · The company plans to start its Phase 2b trial in Huntington’s this year, according to a press release. Wave, in announcing the stop of its trials, touched on plans to open a Phase 1/2 trial this year of a next-generation potential treatment also targeting the mutant protein, which it calls WVE-003. dr. ronald mcnair elementary school addition